Pruritus in anti-DPPX encephalitis
نویسندگان
چکیده
We present a unique case of a patient with anti–dipeptidyl peptidase-like protein 6 (DPPX) encephalitis in which severe pruritus was the cardinal symptom. Anti-DPPX encephalitis is caused by cell surface autoantigens to DPPX, a subunit of the Kv4.2 potassium channel. Most patients had a combination of limbic encephalitis, brainstem dysfunction, diarrhea, and weight loss. We describe a patient with severe pruritus and provide long-term follow-up, offering recommendations for treatment.
منابع مشابه
Anti-DPPX encephalitis: pathogenic effects of antibodies on gut and brain neurons.
OBJECTIVE To characterize pathogenic effects of antibodies to dipeptidyl-peptidase-like protein 6 (DPPX), a subunit of Kv4.2 potassium channels, on gut and brain neurons. METHODS We identified a new patient with anti-DPPX encephalitis and analyzed the effects of the patient's serum and purified immunoglobulin G (IgG), and of serum of a previous patient with anti-DPPX encephalitis, on the acti...
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